Product introduction
Logan QJL-2 automatic counting particle size meter is a kind of test instrument used in high concentration, wide particle size range of particle detection and data analysis, the instrument has been widely used in the field of medicine, semiconductor field and chemical field. The instrument adopts advanced automatic dilution technology, which can quickly and accurately detect the particle distribution in high-concentration samples. The instrument has two detection methods of photoresistance and dual mode, which increases the detection range of particle size. The testing software can analyze the data of fat milk, which meets the requirements of Chinese Pharmacopoeia; Both data integrity and audit trail requirements are met. The instrument cleaning is flexible and convenient, and the sensor can be cleaned independently, which is convenient for users.
Advantages and characteristics of the instrument
1, the sensor adopts photoresist and dual-mode two ways, the detection particle size range is wide, the counting rate is fast, to ensure the accuracy of the detection data.
2,Using two-stage dilution technology, the high-concentration sample can be diluted to the optimal detection concentration of the sensor, and the detection analysis can be carried out efficiently and accurately.
3,.The instrument has two kinds of injection methods: automatic injection and manual injection, which is flexible and convenient. Automatic sampling can ensure the accuracy of the sample amount, and manual sampling can be used to detect small samples.
Hand Sampling
Autoinjection
4,Ultra-high precision resolution
With an ultra-high resolution accuracy of 0.01um, Logan fully automatic particle size detector has 4096 data channels. The data channel refers to the fine degree of segmentation according to particle size within the detection range. The higher the number of channels, the finer the segmentation, and the more real and reliable the displayed particle distribution data.
5,The instrument cleaning is convenient and flexible, and the cleaning time can be freely set, which is convenient for cleaning after detecting different concentrations and different particle sizes.
6,.With a special sensor cleaning circuit, can be directly injected cleaning agent repeated cleaning. After the detection of high-concentration small particle samples, especially samples with a certain viscosity, the sensor is contaminated, and it is difficult to clean the sensor by conventional pipeline cleaning, which will affect the future detection data. Using a dedicated sensor cleaning loop, direct injection of detergent for repeated cleaning, you can quickly clean the sensor without removing the sensor, while the detergent will not affect the rest of the line.
Software advantages and characteristics
Logan automatic particle size detector is controlled by computer software through serial port and data collection, so the software is very powerful. The software has statistical analysis of data and can calculate the volume factor of the data. The calculation formula and data report meet the calculation requirements of fat milk in Chinese Pharmacopoeia. At the same time, it also has the functions of data preservation, report output in different formats, as well as permission management, user management, log generation, electronic fingerprint identification, etc., to meet the requirements of data integrity and audit trail.
Volume factor calculation
Authority management
Test report
Log
Threshold curve
When the threshold curve is calibrated, the maximum value is automatically determined, and the median value of the range can also be automatically searched, so the calibration value is more reasonable and accurate.
Curve superposition
The software test report can optionally superimpose different test curves, which is convenient for users to compare the test results. In particular, the particle aggregation and other changes of the sample after different times can be clearly seen.
Application example
(EMULSION)
Large milk granules in fat milk injection enter human blood vessels during the injection process, causing granuloma, phlebitis and thrombus. At the same time, it will also accompany the blood circulation into the lungs, liver, kidneys and other organs to cause damage. The United States Pharmacopoeia USP729 for fat milk large milk granules (PFAT5) and the 2020 edition of the Chinese Pharmacopoeia regulations "- based on the photoresistance method of single particle optical sensing technology, the weighted total volume of milk granules greater than 5μm shall not exceed 0.05% of the oil phase volume".
.The average size of the conventional emulsion is generally submicron or nanometer, but there are often large milk particles at the tail end of the micron level, which are easy to adsorb small particles, thus affecting the stability of the product. Therefore, for the detection of large milk particle concentration at the tail end, the current formulation and process can be evaluated and optimized accordingly.
(Microrspheres)
Microspheres refer to small spheres or spheroids formed by dissolving or dispersing drugs in natural or synthetic polymer materials. The diameter of microspheres for injection is generally controlled at about 20-50μm. Such microspheres should control both small particles and large particle content. Too small particles are easy to be swallowed by human macrophages, reducing the efficacy; At the same time, too small particles are easy to break through to the capillaries under the skin, leading to serious complications such as embolism. However, the large size of the microsphere will affect the needle penetration. In the preparation of microspheres, the key formulation and processing parameters affect the particle size and porosity of the microspheres, thus affecting the drug release rate. The concentration of polymer in the organic phase, the ratio of phase volume and the pre-saturation of aqueous phase and organic solvent have important effects on the stirring efficiency and the solidification rate of oil droplets, and thus affect the particle size, polydispersity and porosity of microspheres. The AccuSizer A7000 series enables fast and accurate measurement of particle size and particle size distribution, enabling formulation selection and saving research and development time.
(CMP SLURRY)
Chemical-mechanical polishing (CMP) is a key process for wafer surface flattening in IC manufacturing. There are two key performance parameters of CMP slurry in its application: removal rate and number of defects. Both are closely related to the content of large particles at the tail end. When primary particles begin to aggregate, larger particles form. These large particles tend to scratch the wafer, increasing the number of defects. At the same time, these large particles are also more likely to settle, reducing the percentage of solids in the suspended slurry. This results in a lower removal rate. CMP slurry usually needs to pass through the circulation system when it is used in practice. The following figure is the particle count distribution diagram of silicon oxide slurry pumped in the circulation system at different times.
Instrument parameter
Maximum detection concentration: 1010 PCS /ml
Detection method: photoresist method and dual mode method
Injection method: automatic and manual
Automatic injection ring: 1ml and 3ml optional
Maximum number of channels: 512
Mixing bin volume: 30ml
Stirrer: Magnetic stirring, speed adjustable 1-15
Flow rate: 40ml/min,60ml/min
Accuracy: greater than 95%
Repeatability: 10%
Installation conditions: Clean liquid inlet device and waste liquid discharge device are required
Computer requirements: WIN7 or above operating system, USB interface (or COM port)
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